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KMID : 0357920020360060389
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Korean Journal of Pathology
2002 Volume.36 No. 6 p.389 ~ p.393
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Stromelysin-3 Expression in Squamous Intraepithelial Lesions and Invasive Squamous Cell Carcinoma of the Uterine Cervix
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Choi Yoo-Duk
Park Eun-Jung
Nam Jong-Hee
Park Chang-Soo
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Abstract
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Background: Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of epithelial neoplasms. Currently, detected stromelysin-3 (ST-3) (MMP-11) is thought to be associated with invasiveness in epithelial neoplasms. However, the study of the expression of stromelysin-3 in the uterine cervix is yet to be delineated.
Methods: Stromelysin-3 expression in cervical invasive squamous cell carcinoma (SCC) and in squamous intraepithelial lesions (SIL) having potentiality to become invasive was studied by immunohistochemical analysis. We examined the correlation between ST-3 expression and the histopathological parameters of the invasive carcinoma, including growth pattern, lymph node involvement, and degrees of differentiation.
Results: The stromelysin expression rates were as follows; 8.3% in low grade SIL (LSIL), 18.9% in High grade SIL (HSIL), and 75.6% in SCC. A statistical difference in the expression difference was exhibited only between invasive SCC and SIL, but not between LSIL and HSIL, even though HSIL showed a higher expression rate than LSIL. No significant association was found in invasive SCC between ST-3 expression and histopathological parameters.
Conclusion: ST-3 expression is associated with tumor invasiveness in squamous lesions of the uterine cervix and not with histopathological parameters in invasive SCC.
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KEYWORD
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Cervix Neoplasms, Matrix Metalloproteinases, Immunohistochemistry
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